J. In contrast, acute senescence—in the placenta, after wounding or in response to oncogene activation or loss of the tumor suppressor PTEN—triggers DNA damage or p53 signaling to induce p21 and p16Ink4a. The point that is missed is that although some aging processes may be shared among mammals (an assertion that almost all gerontologists would agree with), some may not. Effect of IL-6 on the insulin sensitivity in patients with type 2 diabetes. Dual role of interleukin-6 in regulating insulin sensitivity in murine skeletal muscle. Genet. 11, 289–295 (2011). Circ. Previous SectionNext Section The Cell Culture Phenomenon As the mechanisms of cellular senescence have been increasingly well understood, it has become clear that the process and the end point are separable biological phenomena.
Regulation of collagenase and collagenase mRNA production in early- and late-passage human diploid fibroblasts. Finally, preventing the stresses leading to senescence, but not the senescence program itself, may promote healthy aging and prevent disease. However, following telomere erosion, the capacity of β cells to expand production of insulin is limited by senescence. Hum Genet.97:750-754. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. ^ Williams, G.C. & Poletti, V. Endocrinol.
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